THE DEFINITIVE GUIDE TO TRASTUZUMAB

The phosphorylated HER3 delivers docking sites for p85 subunit of PI3K. The thoroughly activated PI3K complex is generated by binding of p110 subunit of PI3K to p85 which has the capacity to make PIP3 by using phosphorylating the PIP2. AKT binds to PIP3 and is phosphorylated by PDK1 and mTORC2. Phosphorylation of AKT at the two threonine and serin